What is EPIFIX?
EPIFIX® is a placental tissue allograft composed of dehydrated human amnion/chorion membrane (DHACM). It is available in sheet and mesh/fenestrated configurations in a variety of sizes to reduce wastage.
EPIFIX is backed by the most Level I publications among placental-based allografts. The quality of MIMEDX RCTs was evaluated and validated in an assessment initiated by the Agency of Healthcare Research & Quality.1
Protective Environment
EPIFIX acts as a barrier and protects the wound bed to aid in the development of granulation tissue in acute and chronic closures.
Regulatory Proteins
EPIFIX provides a biocompatible human extracellular matrix and contains 300+ regulatory proteins.2-4
Product Advantages
- Demonstrated statistically significant outcomes vs. SOC solutions & other skin substitutes
- Human-derived
- Multiple configurations available for varying demands depending on wound or surgical application desired
- Simple storage and application
- Cost effective: Demonstrated savings in cost and utilization5,6
- Compatible with negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBOT)
Clinical Use Examples
EPIFIX has been adopted by multiple clinical specialties in a variety of applications:
- Acute Wounds
- Chronic Wounds
- Debridements
- Dehisced Wounds
- Diabetic Foot Ulcers (DFUs)
- Venous Leg Ulcers (VLUs)
- Pressure Ulcers (PUs)
- Mohs repair
Making a Difference
EPIFIX is the amniotic skin substitute with an unprecedented depth of clinical data support. Learn how adding EPIFIX to your treatment protocols can impact you and your patients.
EPIFIX Processing & Details
EPIFIX is processed using PURION, a unique patented method for placental-based allografts that is in accordance with the American Association of Tissue Banks (AATB) standards. The product is derived from placental tissue donated by healthy, consenting mothers who have given live Caesarean section birth in the US.
MIMEDX’s patented PURION process preserves extracellular matrix components, including regulatory factors and other matrix-associated proteins. For an additional level of safety, the product is terminally sterilized.
- Snyder DL, et al. Agency for Healthcare Research and Quality. https://www.cms.gov/Medicar…. Published February 2020. Accessed October 13, 2021.
- Koob TJ, Lim JJ, Massee M, Zabek N, Denozière G. Properties of dehydrated human amnion/chorion composite grafts: Implications for wound repair and soft tissue regeneration. J Biomed Mater Res B Appl Biomater. 2014;102(6):1353-1362.
- Lei J, Priddy LB, Lim JJ, Massee M, Koob TJ. Identification of Extracellular Matrix Components and Biological Factors in Micronized Dehydrated Human Amnion/Chorion Membrane. Adv Wound Care (New Rochelle). 2017;6(2):43-53.
- MIMEDX Internal Report. MM-RD-00086, Proteome Characterization of PURION Processed Dehydrated Human Amnion Chorion Membrane (dHACM) and PURION PLUS Processed Dehydrated Human Umbilical Cord (dHUC) Allografts.
- Armstrong DG, Tettelbach WH, Chang TJ, et al. Observed impact of skin substitutes in lower extremity diabetic ulcers: lessons from the Medicare Database (2015-2018). J Wound Care. 2021;30(Sup7):S5-S16.
- Tettelbach WH, Armstrong DG, Chang TJ, et al. Cost-effectiveness of dehydrated human amnion/chorion membrane allografts in lower extremity diabetic ulcer treatment. J Wound Care. 2022 Feb 1;31(Sup2):S10-S31
Resources
Receive industry-leading reimbursement support from MIMEDX specialists.
Reimbursement Support
Patient Insurance Verification Team: 855.882.8480
Product Brochure – HOPD & WCC
Product Brochure – Physician Office
Application Guide
EPIFIX (Q4186)
Dehydrated Human Amnion/Chorion Membrane
| PART NUMBER | SIZE | SQ CM | UPC/GTIN |
| GS-5140 | 14 mm disk | 1.5 | 855310003087 |
| GS-5160 | 16 mm disk | 2 | 855310003001 |
| GS-5180 | 18 mm disk | 2.5 | 855310003414 |
| GS-5024 | 24 mm disk | 4.5 | 855310003391 |
| GS-5220 | 2 cm x 2 cm sheet | 4 | 855310003421 |
| GS-5230 | 2 cm x 3 cm sheet | 6 | 855310003018 |
| GS-5240 | 2 cm × 4 cm sheet | 8 | 855310003438 |
| GS-5330 | 3 cm × 3 cm sheet | 9 | 855310003445 |
| GS-5340 | 3 cm × 4 cm sheet | 12 | 855310003452 |
| GS-5440 | 4 cm × 4 cm sheet | 16 | 855310003025 |
| GS-5350 | 3 cm × 5 cm sheet | 15 | 855310003469 |
| GS-5460 | 4 cm × 6 cm sheet | 24 | 855310003476 |
| GS-5560 | 5 cm × 6 cm sheet | 30 | 855310003650 |
| GS-5770 | 7 cm × 7 cm sheet | 49 | 855310003032 |
| ES-2300 | 2 cm x 3 cm mesh sheet | 4 | 855310003766 |
| ES-3300 | 3.5 cm x 3.5 cm mesh sheet | 8 | 855310003483 |
| ES-3500 | 3 cm x 5 cm mesh sheet | 10 | 855310003858 |
| ES-4400 | 4 cm x 4.5 cm mesh sheet | 10.2 | 855310003872 |
| ES-5500 | 5 cm x 5.5 cm mesh sheet | 16.1 | 856019007062 |
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